Sepsis is a host immune disorder induced by infection. It can lead to multiple organ
dysfunction syndrome (MODS), which has high morbidity and mortality. There has been …

Natural killer (NK) cells are large granular lymphocytes largely recognized for their
importance in tumour surveillance and the host response to viral infections. However, as the …

Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced …

A dramatic decrease in circulating lymphocyte number is regularly described after septic
shock. However, it is unknown how early this alteration develops after diagnosis of shock …

Natural killer (NK) cell function is regulated by a balance of activating and inhibitory signals.
Tumor necrosis factor (TNF) is an inflammatory cytokine ubiquitous across homeostasis and …

Lactate significantly impacts immune cell function in sepsis and septic shock, transcending
its traditional view as just a metabolic byproduct. This review summarizes the role of lactate …

Sepsis is a systemic inflammatory response syndrome due to infection. The incidence rate is
estimated to be up to 19 million cases worldwide per year and the number of cases is rising …

Accumulating studies have recognized microRNAs (miRs) and long noncoding RNAs
(lncRNAs) as important molecules involved in the mediation of various biological processes …

The implementation of new markers of bacterial infection into clinical practice is hindered by
their costs. We assessed the potential use of the neutrophil to lymphocyte count ratio …

Introduction Our aim was to define early changes of lymphocytes and of NK cells in severe
sepsis and to correlate them with serum levels of soluble triggering receptor expressed on …