Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Oceans are a rich source of structurally unique bioactive compounds from the perspective of
potential therapeutic agents. Marine peptides are a particularly interesting group of …

Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological
studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric …

While prevention is a bedrock of public health, innovative therapeutics are needed to
complement the armamentarium of interventions required to achieve disease control and …

Cyclization is an important post-translational modification of peptides and proteins that
confers key advantages such as protection from proteolytic degradation, altered solubility …

Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …

Mycobacterium tuberculosis Clp proteases are targeted by several antitubercular
compounds, including cyclomarin A (CymA). CymA exerts its toxicity by binding to AAA+ …

An efficient synthetic protocol for the stereoselective synthesis of cyclomarin A is reported.
Key steps in the syntheses of the building blocks are an asymmetric chelate–enolate …

Natural products have made a crucial and unique contribution to human health, and this is
especially true in the case of malaria, where the natural products quinine and artemisinin …

Parasitic diseases still compromise human health. Some of the currently available
therapeutic drugs have limitations considering their adverse effects, questionable efficacy …