Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

The function of somatic stem cells declines with age. Understanding the molecular
underpinnings of this decline is key to counteract age-related disease. Here, we report a …

Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain. The
ventricular–subventricular zone (V‐SVZ), adjacent to the lateral ventricles, gives rise to …

Adult neurogenesis is the process of producing new neurons from neural stem cells (NSCs)
for integration into the brain circuitry. Neurogenesis occurs throughout life in the ventricular …

Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …

Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

Neural stem cells (NSCs) represent a remarkable developmental unit, necessary for the
proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to …

Stem cells show intrinsic interferon signalling, which protects them from viral infections at all
ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to …

Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell
analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we …