Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

Oxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal
cancer. OXA-induced peripheral neurotoxcity (OIPN) is a comprehensive adverse reaction of …

Chemotherapy induced peripheral neuropathy (CIPN) is a type of neuropathic pain that is a
major dose-limiting side-effect of potentially curative cancer chemotherapy treatment …

Anti-cancer drugs such as vincristine, paclitaxel, oxaliplatin, cisplatin and bortezomib are
well reported to exert direct and indirect effects on sensory nerves to alter the amplitude of …

Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …

Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting
from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it …

Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and
potentially permanent side effect of cancer treatment. For the management of OIPN, accurate …

Neurotoxicity is the limiting side effect of the anticancer agent oxaliplatin. A tangled panel of
symptoms, sensory loss, paresthesia, dysesthesia, and pain may be disabling for patients …

Background Oxaliplatin is one of the first-line drugs in solid tumors treatment. However,
neuropathy is a devastating side effect leading to poor compliance and treatment cessation …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-
limiting side effect of many chemotherapy regimens yet has limited treatments due to …