Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies

P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

H Zhang, Y Wang, Y Wang, X Li, S Wang… - European Journal of …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

β-Carboline as a privileged scaffold for multitarget strategies in Alzheimer's disease therapy

A Beato, A Gori, B Boucherle… - Journal of Medicinal …, 2021 - ACS Publications
The natural β-carboline alkaloids display similarities with neurotransmitters that can be
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …

Traditional Chinese medicine for anti-Alzheimer's disease: berberine and evodiamine from Evodia rutaecarpa

Z Fang, Y Tang, J Ying, C Tang, Q Wang - Chinese medicine, 2020 - Springer
Alzheimer's disease (AD) is one of the most common diseases in elderly people with a high
incidence of dementia at approximately 60–80%. The pathogenesis of AD was quite …

Merged tacrine-based, multitarget-directed acetylcholinesterase inhibitors 2015–present: Synthesis and biological activity

TJ Eckroat, DL Manross, SC Cowan - International journal of molecular …, 2020 - mdpi.com
Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-
mediated neuronal transmission in the central nervous system, contains a unique structure …

Discovery of highly selective and nanomolar carbamate-based butyrylcholinesterase inhibitors by rational investigation into their inhibition mode

E Sawatzky, S Wehle, B Kling, J Wendrich… - Journal of medicinal …, 2016 - ACS Publications
Butyrylcholinesterase (BChE) is a promising target for the treatment of later stage cognitive
decline in Alzheimer's disease. A set of pseudo-irreversible BChE inhibitors with high …

Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease

J Wu, X Kou, H Ju, H Zhang, A Yang, R Shen - Bioorganic & Medicinal …, 2021 - Elsevier
A series of naringenin derivatives were designed and synthesized as multifunctional anti-
Alzheimer's disease (AD) agents. The results showed that these derivatives displayed …

Mps1–Targeted Molecular Design of Melatonin for Broad-Spectrum Antifungal Agent Discovery

H Cai, J Li, L Ran, Y Chen, H Teng - Journal of Agricultural and …, 2024 - ACS Publications
Melatonin, a multifunctional class of natural products, has demonstrated antifungal activity,
making it a promising candidate for developing antifungal agents. The mitogen-activated …

Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid

GZ Yang, J Zhang, JW Peng, ZJ Zhang… - European Journal of …, 2020 - Elsevier
The prevention and control of plant diseases and insect pests is the most crucial issue facing
crop protection. To discover novel pesticide candidates with diverse chemical structures …

Utilization of isatoic anhydride in the syntheses of various types of quinazoline and quinazolinone derivatives

SY Abbas, KAM El-Bayouki… - Synthetic …, 2016 - Taylor & Francis
Isatoic anhydride has attracted a great deal of attention in recent decades. A review of the
methods of preparation of all known quinazoline and quinazolinone derivatives is given …