Highlights•Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and
chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin …

Heparin, a highly sulfated glycosaminoglycan, is considered an indispensable anticoagulant
with diverse therapeutic applications and has been a mainstay in medical practice for nearly …

Heparosan as an acidic polysaccharide is mainly applied for heparin biosynthesis and drug
delivery. Escherichia coli Nissle 1917 (EcN) naturally synthesizes and secrets heparosan as …

Glycosaminoglycans (GAGs) are naturally occurring acidic polysaccharides with wide
applications in pharmaceuticals, cosmetics, and health foods. The diverse biological …

Fungal sulfated polysaccharides (SPS) have been used in the pharmaceutical industry. In
this study, sodium sulfate was employed as an elicitor to induce stress on the mycelia of …

Abstract Fermentative poly-3-hydroxybutyrate (PHB) production is mainly limited by the cost
of raw material. In this present study, low-cost feedstock viz., millet bran residue (MBRH) and …

Background The disposal of biomass waste from the agro-industry is a global challenge due
to its negative environmental impacts. The global fishing industry and aquaculture in 2018 …

Heparin is one of the most widely used natural drugs, and has been the preferred
anticoagulant and antithrombotic agent in the clinical setting for nearly a century. Heparin …

The safe production of β-alanine (BA) has attracted significant attention by its multifaceted
applications in pharmaceutical, polymer, and nutrition. The extant high-yielding chemical …

Abstract Low Molecular Weight Heparins (LMWHs) are well-established for use in the
prevention and treatment of thrombotic diseases, and as a substitute for unfractionated …