Molecular genetic mechanisms in age-related macular degeneration

A Shughoury, DD Sevgi, TA Ciulla - Genes, 2022 - mdpi.com
Age-related macular degeneration (AMD) is among the leading causes of irreversible
blindness worldwide. In addition to environmental risk factors, such as tobacco use and diet …

Matrix metalloproteinases in age-related macular degeneration (AMD)

L García-Onrubia, FJ Valentín-Bravo… - International Journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) is a complex, multifactorial and progressive retinal
disease affecting millions of people worldwide. In developed countries, it is the leading …

CRISPR/Cas9—A Promising Therapeutic Tool to Cure Blindness: Current Scenario and Future Prospects

I Ahmad - International Journal of Molecular Sciences, 2022 - mdpi.com
CRISPR-based targeted genome editing is bringing revolutionary changes in the research
arena of biological sciences. CRISPR/Cas9 has been explored as an efficient therapeutic …

Construction of an Exudative Age-Related Macular Degeneration Diagnostic and Therapeutic Molecular Network Using Multi-Layer Network Analysis, a Fuzzy Logic …

H Latifi-Navid, A Barzegar Behrooz, S Jamehdor… - Pharmaceuticals, 2023 - mdpi.com
Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible
visual impairment in the elderly. The current management of nAMD is limited and involves …

Learning from fifteen years of genome-wide association studies in age-related macular degeneration

T Strunz, C Kiel, BL Sauerbeck, BHF Weber - Cells, 2020 - mdpi.com
Over the last 15 years, genome-wide association studies (GWAS) have greatly advanced
our understanding of the genetic landscape of complex phenotypes. Nevertheless, causal …

VEGFA Haplotype and VEGF-A and VEGF-R2 Protein Associations with Exudative Age-Related Macular Degeneration

A Vilkeviciute, D Cebatoriene, L Kriauciuniene… - Cells, 2022 - mdpi.com
Our study aimed to reveal the associations between VEGFA SNPs (rs1570360, rs699947,
rs3025033, and rs2146323), their haplotypes, VEGF-A and VEGF-R2 serum concentrations …

Targeted Gene Candidates for Treatment and Early Diagnosis of Age‐Related Macular Degeneration

E Cinici, O Caglar, ME Arslan… - BioMed Research …, 2021 - Wiley Online Library
Age‐related macular degeneration (AMD) is an eye disease that impairs the sharp and
central vision need for daily activities. Recent advances in molecular biology research not …

Association of ARMS2, HTRA1 and CFH genes polymorphisms in patients with age-related macular degeneration in the Malaysian population

F Ismail, SM Junit, LC Chin, JJ Jayapalan… - Egyptian Journal of …, 2024 - Springer
Background Despite extensive research efforts, understanding the precise causes and
molecular underpinnings of age-related macular degeneration (AMD) remains elusive …

KCTD10 Biology: An Adaptor for the Ubiquitin E3 Complex Meets Multiple Substrates: Emerging Divergent Roles of the cullin‐3/KCTD10 E3 Ubiquitin Ligase Complex …

M Maekawa, S Higashiyama - BioEssays, 2020 - Wiley Online Library
Protein ubiquitination constitutes a post‐translational modification mediated by ubiquitin
ligases whereby ubiquitinated substrates are degraded through the proteasomal or …

[PDF][PDF] Sporda Damar Mekanizmasını Etkileyen Genetik Faktörler: Geleneksel Derleme.

S KAHYA - Turkiye Klinikleri Journal of Sports Sciences, 2023 - academia.edu
Mevcut çalışmamız, sporda genetik etmenlerin damar mekanizması üzerindeki etkisini
incelemek amacıyla yapılmıştır. Damarlar, sportif performansın etkili ve verimli bir şeklide …