Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

2622 Stroke September 2017 cerebral edema and symptomatic intracranial hemorrhage,
which defines a malignant profile. 27 Because such patients have lowest rates of favorable …

Background and Purpose—Recent randomized trials have proven the benefit of intra-arterial
treatment (IAT) with retrievable stents in acute ischemic stroke. Patients with poor or absent …

Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion.
Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a …

Following the success of recent endovascular trials, endovascular therapy has emerged as
an exciting addition to the arsenal of clinical management of patients with acute ischemic …

The brain vasculature has been increasingly recognized as a key player that directs brain
development, regulates homeostasis, and contributes to pathological processes. Following …

Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion,
may impact infarct evolution but have not previously been demonstrated in humans. We …

BACKGROUND AND PURPOSE: Large admission DWI lesion volumes are associated with
poor outcomes despite acute stroke treatment. The primary aims of our study were to …

Background and Purpose—After large-vessel intracranial occlusion, the fate of the ischemic
penumbra, and ultimately final infarct volume, largely depends on tissue perfusion. In this …