Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and
thick filament proteins within the myocyte. The thin filament consists of the proteins actin …

BACKGROUND: Modulating myosin function is a novel therapeutic approach in patients with
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …

To understand how pathology-induced changes in contractile protein isoforms modulate
cardiac muscle function, it is necessary to quantify the temporal-mechanical properties of …

One of the complexities of understanding the pathology of familial forms of cardiac diseases
is the level of mutation incorporation in sarcomeres. Computational models of the sarcomere …

Hallmark features of systolic heart failure are reduced contractility and impaired metabolic
flexibility of the myocardium. Cardiomyocytes (CMs) with elevated deoxy ATP (dATP) via …

Cardiac remodeling is regulated at the cellular level by coordinated responses to
biomechanical signals, such as actomyosin contractile forces, hemodynamic loading, and …

Hypertrophic cardiomyopathy (HCM) is a genetic disease of the heart characterized by
thickening of the left ventricle (LV), hypercontractility, and impaired relaxation. HCM is …

Cardiac muscle contraction is regulated via Ca2+ exchange with the hetero-trimeric troponin
complex located on the thin filament. Binding of Ca2+ to cardiac troponin C, a Ca2+ sensing …

Dilated cardiomyopathy (DCM) is a life-threatening form of heart disease that is typically
characterized by progressive thinning of the ventricular walls, chamber dilation, and systolic …