Antimicrobial peptides and small molecules targeting the cell membrane of Staphylococcus aureus
Clinical management of Staphylococcus aureus infections presents a challenge due to the
high incidence, considerable virulence, and emergence of drug resistance mechanisms …
high incidence, considerable virulence, and emergence of drug resistance mechanisms …
Antimicrobial peptides: sustainable application informed by evolutionary constraints
X Chen, J Han, X Cai, S Wang - Biotechnology Advances, 2022 - Elsevier
The proliferation and global expansion of multidrug-resistant (MDR) bacteria have
deepened the need to develop novel antimicrobials. Antimicrobial peptides (AMPs) are …
deepened the need to develop novel antimicrobials. Antimicrobial peptides (AMPs) are …
Resistance Evolution Against Antimicrobial Peptides in Staphylococcus aureus Alters Pharmacodynamics Beyond the MIC
B El Shazely, G Yu, PR Johnston, J Rolff - Frontiers in microbiology, 2020 - frontiersin.org
Antimicrobial peptides (AMPs) have been proposed as a promising class of new
antimicrobials partly because they are less susceptible to bacterial resistance evolution. This …
antimicrobials partly because they are less susceptible to bacterial resistance evolution. This …
Understanding mechanisms of virulence in MRSA: implications for antivirulence treatment strategies
ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) is a
widespread pathogen, often causing recurrent and deadly infections in the hospital and …
widespread pathogen, often causing recurrent and deadly infections in the hospital and …
[HTML][HTML] Dietary nutrients mediate intestinal host defense peptide expression
The intestinal tract is the shared locus of intestinal epithelial cells, immune cells, nutrient
digestion and absorption, and microbial survival. The gut in animals faces continuous …
digestion and absorption, and microbial survival. The gut in animals faces continuous …
Bacteria primed by antimicrobial peptides develop tolerance and persist
Antimicrobial peptides (AMPs) are key components of innate immune defenses. Because of
the antibiotic crisis, AMPs have also come into focus as new drugs. Here, we explore …
the antibiotic crisis, AMPs have also come into focus as new drugs. Here, we explore …
Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis
AA Joshi, M Vocanson, JF Nicolas, P Wolf… - Frontiers in …, 2023 - frontiersin.org
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly
affects the patient's quality of life. A disrupted skin barrier, type 2 cytokine-dominated …
affects the patient's quality of life. A disrupted skin barrier, type 2 cytokine-dominated …
The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria
Antibiotic resistance is a global issue that threatens our progress in healthcare and life
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …
Efficiency of antimicrobial peptides against multidrug-resistant staphylococcal pathogens
MNT Le, M Kawada-Matsuo… - Frontiers in …, 2022 - frontiersin.org
Antibiotics play a vital role in saving millions of lives from fatal infections; however, the
inappropriate use of antibiotics has led to the emergence and propagation of drug …
inappropriate use of antibiotics has led to the emergence and propagation of drug …
Antibacterial Peptides Resistance in Staphylococcus aureus: Various Mechanisms and the Association with Pathogenicity
M Kawada-Matsuo, MNT Le, H Komatsuzawa - Genes, 2021 - mdpi.com
Staphylococcus aureus is a bacterium that mainly colonizes the nasal cavity and skin. To
colonize the host, it is necessary for S. aureus to resist many antibacterial factors derived …
colonize the host, it is necessary for S. aureus to resist many antibacterial factors derived …