Pre-eclampsia

E Dimitriadis, DL Rolnik, W Zhou… - Nature reviews Disease …, 2023 - nature.com
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Evaluating the promise of inclusion of African ancestry populations in genomics

AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

V Steinthorsdottir, R McGinnis, NO Williams… - Nature …, 2020 - nature.com
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal
health. In genome-wide association meta-analysis of European and Central Asian mothers …

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

S Sanchez-Roige, MV Jennings, HHA Thorpe… - Translational …, 2023 - nature.com
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …

Alcohol and hypertension—new insights and lingering controversies

IB Puddey, TA Mori, AE Barden, LJ Beilin - Current hypertension reports, 2019 - Springer
Abstract Purpose of Review To examine outstanding issues in the relationship of alcohol to
hypertension. These include whether the increase in BP with alcohol is causally related, the …

[HTML][HTML] The HERITAGE Family Study: a review of the effects of exercise training on cardiometabolic health, with insights into molecular transducers

MA Sarzynski, TK Rice, JP Després… - Medicine and science …, 2022 - ncbi.nlm.nih.gov
The aim of the HERITAGE Family Study was to investigate individual differences in response
to a standardized endurance exercise program, the role of familial aggregation, and the …

Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women

B Adedokun, Z Du, G Gao, TU Ahearn… - Nature …, 2021 - nature.com
Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first
identify variants that are associated with breast cancer at P< 0.05 from African ancestry …

Genome-wide study on 72,298 individuals in Korean biobank data for 76 traits

K Nam, J Kim, S Lee - Cell Genomics, 2022 - cell.com
Genome-wide association studies (GWAS) on diverse ancestry groups are lacking, resulting
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …

Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines

Y Kokubo, S Padmanabhan, Y Iwashima… - … Health and Preventive …, 2019 - Springer
Risk factors for hypertension consist of lifestyle and genetic factors. Family history and twin
studies have yielded heritability estimates of BP in the range of 34–67%. The most recent …

Gene-lifestyle interactions in the genomics of human complex traits

V Laville, T Majarian, YJ Sung, K Schwander… - European Journal of …, 2022 - nature.com
The role and biological significance of gene-environment interactions in human traits and
diseases remain poorly understood. To address these questions, the CHARGE Gene …