IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

K Taniguchi, M Karin - Seminars in immunology, 2014 - Elsevier
Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

S Qian, O Golubnitschaja, X Zhan - Epma Journal, 2019 - Springer
A strong relationship exists between tumor and inflammation, which is the hot point in cancer
research. Inflammation can promote the occurrence and development of cancer by …

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

TL Putoczki, S Thiem, A Loving, RA Busuttil, NJ Wilson… - Cancer cell, 2013 - cell.com
Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer" hallmarks" through downstream activation of the gp130/STAT3 …

[HTML][HTML] Emerging roles for IL-11 in inflammatory diseases

KY Fung, C Louis, RD Metcalfe, CC Kosasih, IP Wicks… - Cytokine, 2022 - Elsevier
Abstract Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the
pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also …

Adipocytokines and disease progression in endometrial cancer: a systematic review

I Ray, LB Meira, A Michael, PE Ellis - Cancer and Metastasis Reviews, 2022 - Springer
The objective of the study was to document the effect of adipocytokines on endometrial
cancer progression. A search of the databases CINAHL, Medline, PubMed, Cochrane, Web …

The role of the inflammatory microenvironment in thyroid carcinogenesis

LL Cunha, MA Marcello, LS Ward - Endocrine-related cancer, 2014 - erc.bioscientifica.com
Immune responses against thyroid carcinomas have long been demonstrated and
associations between inflammatory microenvironment and thyroid carcinomas repeatedly …

A TrkB–STAT3–miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells

W Bao, HH Wang, FJ Tian, XY He, MT Qiu, JY Wang… - Molecular cancer, 2013 - Springer
Abstract Background We previously identified TrkB as an oncogene involved in promoting
metastasis in endometrial carcinoma (EC). Here, we sought to delineate the effect of …

Molecular pathways: IL11 as a tumor-promoting cytokine—translational implications for cancers

M Ernst, TL Putoczki - Clinical Cancer Research, 2014 - AACR
Emerging evidence suggests that cytokines produced by inflammatory cells act as rheostats
to link the degree of wounding and local inflammation to epithelial cell survival, proliferation …

Changes in the extracellular matrix in endometrial and cervical cancer: a systematic review

T Padežnik, A Oleksy, A Cokan, I Takač… - International Journal of …, 2023 - mdpi.com
Endometrial and cervical cancers are the two most common gynaecological malignancies
and among the leading causes of death worldwide. The extracellular matrix (ECM) is an …

[HTML][HTML] IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer

Q Zhao, L Qian, Y Guo, J Lü, D Li, H Xie, Q Wang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Emerging evidence has indicated the aberrant expression of PIWI-interacting RNAs
(piRNAs) in human cancer cells to regulate tumor development and progression by …