In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The
glucose transporter GLUT4 is dynamically sorted and retained intracellularly and …

Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …

Dendritic spines are the major sites of synaptic transmission in the central nervous system.
Alterations in the strength of synaptic connections directly affect the neuronal …

Actin is the most abundant protein in most eukaryotic cells. It is highly conserved and
participates in more protein-protein interactions than any known protein. These properties …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …

The p21 Rho-family of small GTPases are master regulators of actin cytoskeleton
rearrangements. Their functions have been well characterized in terms of their effects toward …