[HTML][HTML] The quest for multiscale brain modeling

E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …

Novel cerebello-amygdala connections provide missing link between cerebellum and limbic system

SJ Jung, K Vlasov, AF D'Ambra, A Parigi… - Frontiers in systems …, 2022 - frontiersin.org
The cerebellum is emerging as a powerful regulator of cognitive and affective processing
and memory in both humans and animals and has been implicated in affective disorders …

An overview of brain-like computing: Architecture, applications, and future trends

W Ou, S Xiao, C Zhu, W Han, Q Zhang - Frontiers in neurorobotics, 2022 - frontiersin.org
With the development of technology, Moore's law will come to an end, and scientists are
trying to find a new way out in brain-like computing. But we still know very little about how …

A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics

RM Lorenzi, A Geminiani, Y Zerlaut… - PLOS Computational …, 2023 - journals.plos.org
Mean-field (MF) models are computational formalism used to summarize in a few statistical
parameters the salient biophysical properties of an inter-wired neuronal network. Their …

Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit

R De Schepper, A Geminiani, S Masoli… - Communications …, 2022 - nature.com
The cerebellar network is renowned for its regular architecture that has inspired foundational
computational theories. However, the relationship between circuit structure, function and …

Cerebellum involvement in dystonia during associative motor learning: insights from a data-driven spiking network model

A Geminiani, A Mockevičius, E D'Angelo… - Frontiers in Systems …, 2022 - frontiersin.org
Dystonia is a movement disorder characterized by sustained or intermittent muscle
contractions causing abnormal, often repetitive movements, postures, or both. Although …

Towards a bio-inspired real-time neuromorphic cerebellum

PA Bogdan, B Marcinnò, C Casellato… - Frontiers in cellular …, 2021 - frontiersin.org
This work presents the first simulation of a large-scale, bio-physically constrained
cerebellum model performed on neuromorphic hardware. A model containing 97,000 …

An adaptive generalized leaky integrate-and-fire model for hippocampal CA1 pyramidal neurons and interneurons

A Marasco, E Spera, V De Falco, A Iuorio… - Bulletin of Mathematical …, 2023 - Springer
Full-scale morphologically and biophysically realistic model networks, aiming at modeling
multiple brain areas, provide an invaluable tool to make significant scientific advances from …

Response dynamics in an olivocerebellar spiking neural network with non-linear neuron properties

A Geminiani, A Pedrocchi, E D'Angelo… - Frontiers in …, 2019 - frontiersin.org
Sensorimotor signals are integrated and processed by the cerebellar circuit to predict
accurate control of actions. In order to investigate how single neuron dynamics and …

Brain-inspired spiking neural network controller for a neurorobotic whisker system

A Antonietti, A Geminiani, E Negri, E D'Angelo… - Frontiers in …, 2022 - frontiersin.org
It is common for animals to use self-generated movements to actively sense the surrounding
environment. For instance, rodents rhythmically move their whiskers to explore the space …