The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Efficient folding of many newly synthesized proteins depends on assistance from molecular
chaperones, which serve to prevent protein misfolding and aggregation in the crowded …

The past 20 years have seen enormous progress in the understanding of the mechanisms
used by the enteric bacterium Escherichia coli to promote protein folding, support protein …

Cells are faced with the task of folding thousands of different polypeptides into a wide range
of conformations. For many proteins, the folding process requires the action of molecular …

Methylating agents generate cytotoxic and mutagenic DNA damage. Cells use 3-
methyladenine-DNA glycosylases to excise some methylated bases from DNA, and suicidal …

The secretory production of recombinant proteins by the Gram-negative bacterium
Escherichia coli has several advantages over intracellular production as inclusion bodies. In …

The early events in the life of newly synthesized proteins in the cellular environment are
remarkably complex. Concurrently with their synthesis by the ribosome, nascent …

Introduction Molecular chaperones prevent aggregation and misfolding of proteins in the
cellular environment and are thus central to maintaining protein homeostasis. Molecular …

Newly synthesized proteins require the assistance of molecular chaperones to efficiently fold
into functional three-dimensional structures in the crowded environment of the cell. At first …

Recent years have witnessed major advances in our understanding of the structural basis of
protein aggregation on several fronts. Firstly, high-resolution structural information that …