Hong Kong employed a strategy of intermittent public health and social measures alongside
increasingly stringent travel regulations to eliminate domestic SARS-CoV-2 transmission. By …

Insertions and deletions (indels) in human genomes are associated with a wide range of
phenotypes, including various clinical disorders. High-throughput, next generation …

Infection with human cytomegalovirus (HCMV) can cause severe complications in
immunocompromised individuals and congenitally infected children. Characterizing …

The study of genetic minority variants is fundamental to the understanding of complex
processes such as evolution, fitness, transmission, virulence, heteroresistance and drug …

Objectives Fluoroquinolone resistance poses a threat to the successful treatment of
tuberculosis. WGS, and the subsequent detection of catalogued resistance-associated …

Genomic sequencing of clinical samples to identify emerging variants of SARS-CoV-2 has
been a key public health tool for curbing the spread of the virus. As a result, an …

Malaria causes> 600 thousand fatalities each year, with most cases attributed to the human-
infectious Plasmodium falciparum species. Many rodent-infectious Plasmodium species, like …

Influenza viruses exhibit considerable diversity between hosts. Additionally, different
quasispecies can be found within the same host. High-throughput sequencing technologies …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP), driven by somatic mutations in
leukemia-associated genes, confers increased risk of hematologic malignancies …

Here a bioinformatic pipeline VVV has been developed to analyse viral populations in a
given sample from Next Generation Sequencing (NGS) data. To date, handling large …