Radiation necrosis, pseudoprogression, pseudoresponse, and tumor recurrence: imaging challenges for the evaluation of treated gliomas

A Zikou, C Sioka, GA Alexiou… - Contrast media & …, 2018 - Wiley Online Library
Glioblastoma (GBM) is the most common primary malignant type of brain neoplasm in adults
and carries a dismal prognosis. The current standard of care for GBM is surgical excision …

[HTML][HTML] Biomarkers for clinical benefit of immune checkpoint inhibitor treatment—a review from the melanoma perspective and beyond

K Buder-Bakhaya, JC Hassel - Frontiers in immunology, 2018 - frontiersin.org
Background Immune checkpoint inhibition (ICI) with anti-CTLA-4 and/or anti-PD-1
antibodies is standard treatment for metastatic melanoma. Anti-PD-1 (pembrolizumab …

Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases

ZA Kohutek, Y Yamada, TA Chan, CW Brennan… - Journal of neuro …, 2015 - Springer
Radionecrosis is a well-characterized effect of stereotactic radiosurgery (SRS) and is
occasionally associated with serious neurologic sequelae. Here, we investigated the …

[HTML][HTML] Differentiating radiation-induced necrosis from recurrent brain tumor using MR perfusion and spectroscopy: a meta-analysis

MT Chuang, YS Liu, YS Tsai, YC Chen, CK Wang - PloS one, 2016 - journals.plos.org
Purpose This meta-analysis examined roles of several metabolites in differentiating
recurrent tumor from necrosis in patients with brain tumors using MR perfusion and …

[HTML][HTML] Diagnostic accuracy of PET for differentiating true glioma progression from post treatment-related changes: a systematic review and meta-analysis

M Cui, RI Zorrilla-Veloz, J Hu, B Guan, X Ma - Frontiers in Neurology, 2021 - frontiersin.org
Purpose: To evaluate the diagnostic accuracy of PET with different radiotracers and
parameters in differentiating between true glioma progression (TPR) and post treatment …

Diagnostic accuracy of PET tracers for the differentiation of tumor progression from treatment-related changes in high-grade glioma: a systematic review and …

PL de Zwart, BRJ van Dijken, GA Holtman… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Posttreatment high-grade gliomas are usually monitored with contrast-enhanced MRI, but its
diagnostic accuracy is limited as it cannot adequately distinguish between true tumor …

11C–MET PET/MRI for detection of recurrent glioma

C Deuschl, J Kirchner, TD Poeppel… - European journal of …, 2018 - Springer
Introduction Radiological assessment of brain tumors is widely based on the Radiology
Assessment of Neuro-Oncology (RANO) criteria that consider non-specific T1 and T2 …

Brain tumors: an update on clinical PET research in gliomas

K Herholz - Seminars in nuclear medicine, 2017 - Elsevier
A previous review published in 2012 demonstrated the role of clinical PET for diagnosis and
management of brain tumors using mainly FDG, amino acid tracers, and 18 F …

PET imaging of proliferation with pyrimidines

OS Tehrani, AF Shields - Journal of Nuclear Medicine, 2013 - Soc Nuclear Med
Several new tracers are being developed for use with PET to assess pathways that are
altered in cancers, including energy use, cellular signaling, transport, and proliferation …

Radiation necrosis from stereotactic radiosurgery—how do we mitigate?

BA Vellayappan, T McGranahan, J Graber… - … treatment options in …, 2021 - Springer
Opinion statement Intracranial stereotactic radiosurgery (SRS) is an effective and convenient
treatment for many brain conditions. Data regarding safety come mostly from retrospective …