The pentose phosphate pathway in health and disease
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
Metabolomics and isotope tracing
Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival.
Here we show that this comes at a significant cost for cancer cells with high levels of …
Here we show that this comes at a significant cost for cancer cells with high levels of …
Mitochondrial integrated stress response controls lung epithelial cell fate
Abstract Alveolar epithelial type 1 (AT1) cells are necessary to transfer oxygen and carbon
dioxide between the blood and air. Alveolar epithelial type 2 (AT2) cells serve as a partially …
dioxide between the blood and air. Alveolar epithelial type 2 (AT2) cells serve as a partially …
Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage
AM Cameron, A Castoldi, DE Sanin… - Nature …, 2019 - nature.com
The adoption of Warburg metabolism is critical for the activation of macrophages in
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …
MCART1/SLC25A51 is required for mitochondrial NAD transport
The nicotinamide adenine dinucleotide (NAD+/NADH) pair is a cofactor in redox reactions
and is particularly critical in mitochondria as it connects substrate oxidation by the …
and is particularly critical in mitochondria as it connects substrate oxidation by the …
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell
cycle and engaging acquired effector functions. Metabolic reprogramming from the naive …
cycle and engaging acquired effector functions. Metabolic reprogramming from the naive …
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD),
with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that …
with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that …
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS
The SLC25 carrier family consists of 53 transporters that shuttle nutrients and co-factors
across mitochondrial membranes. The family is highly redundant and their transport …
across mitochondrial membranes. The family is highly redundant and their transport …
Hepatic NADH reductive stress underlies common variation in metabolic traits
The cellular NADH/NAD+ ratio is fundamental to biochemistry, but the extent to which it
reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the …
reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the …