Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid
post-translational modifications that are required for the transforming activity of many …

BACKGROUND Compelling evidence indicates that paclitaxel kills cancer cells through the
induction of apoptosis. Paclitaxel binds microtubules and causes kinetic suppression …

The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions
as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The involvement of the RAS superfamily of monomeric GTPases in carcinogenesis is
increasingly being appreciated. A complex array of post-translational modifications and a …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Ras proteins are guanine nucleotide–binding proteins that play pivotal roles in the control of
normal and transformed cell growth and are among the most intensively studied proteins of …

Desiccation of plants during drought can be detrimental to agricultural production. The
phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in …

Different tumors have different aberrations in signaling and growth stimulation pathways that
drive cancer growth. An understanding of these processes is key to the development of new …

Some proteins undergo posttranslational modification by the addition of an isoprenyl lipid
(farnesyl-or geranylgeranyl-isoprenoid) to a cysteine residue proximal to the C terminus …