Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

Highlights•The most common interaction is a short, negatively-charged peptide binding
across a groove formed by two to three TPRs.•Longer peptides bind in an extended …

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …

Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue
architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the …

Orientation of the cell division axis is essential for the correct development and maintenance
of tissue morphology, both for symmetric cell divisions and for the asymmetric distribution of …

The macromolecular crystallography beamline BL17U1 at the Shanghai Synchrotron
Radiation Facility (SSRF) is the first dedicated macromolecular crystallography (MX) …

Liquid–liquid phase separation (LLPS) of biomolecules drives the formation of subcellular
compartments with distinct physicochemical properties. These compartments, free of lipid …

Epithelia form intelligent, dynamic barriers between the external environment and an
organism's interior. Intercellular cadherin-based adhesions adapt and respond to …

In any mitotic cell, the orientation of the mitotic spindle determines the orientation of the
cleavage plane and therefore the position of the two daughter cells. When combined with …