DAMPs and sterile inflammation in drug hepatotoxicity

R Yang, TI Tonnesseen - Hepatology international, 2019 - Springer
Drug hepatotoxicity is the leading cause of acute liver failure (ALF) in the developed
countries. The early diagnosis and treatment are still problematic, and one important reason …

The immunological mechanisms and therapeutic potential in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Q Li, F Chen, F Wang - Cell & Bioscience, 2022 - Springer
Acute liver failure caused by drug overdose is a significant clinical problem in developed
countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its …

DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury

S Du, G Chen, B Yuan, Y Hu, P Yang, Y Chen… - Cellular & molecular …, 2021 - nature.com
Liver damage upon exposure to ionizing radiation (IR), whether accidental or therapeutic,
can contribute to liver dysfunction. Currently, radiotherapy (RT) is used for various cancers …

Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production

AD Hildreth, ET Padilla, RY Tafti, AR Legala… - Cell reports, 2023 - cell.com
Tissue-resident immune cells are critical to the initiation and potentiation of inflammation.
However, the tissue-protective cellular communication networks initiated by resident …

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway

P Shen, L Han, G Chen, Z Cheng, Q Liu - Inflammation, 2022 - Springer
Emodin is a natural bioactive compound from traditional Chinese herbs that exerts anti-
inflammatory, antioxidant, anticancer, hepatoprotective, and neuroprotective effects …