Recognition of pathogens and altered self must be efficient and highly specific to orchestrate
appropriate responses while limiting excessive inflammation and autoimmune reaction to …

Abstract Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that recognises the double-
strand DNA. AIM2 inflammasome is a protein platform in the cell that initiates innate immune …

Abstract Absent in melanoma 2 (AIM2) has been reported to be a component of
inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and …

In modern vaccines, adjuvants can be sophisticated immunological tools to promote robust
and long-lasting protection against prevalent diseases. However, there is an urgent need to …

Abstract Absent in melanoma 2 (AIM2) is a novel member of interferon (IFN)‐inducible
PYHIN proteins. In innate immune cells, AIM2 servers as a cytoplasmic double‐stranded …

Cardiac fibrosis can lead to heart failure, arrhythmia, and sudden cardiac death,
representing one of the leading causes of death due to cardiovascular diseases. Cardiac …

Acute kidney injury (AKI) is a frequent clinical complication in critically ill patients, and it
rapidly develops into renal failure with high morbidity and mortality. However, other than …

Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic
complications, which seriously affect the quality of life and physical and mental health of …

Coxsackievirus B3 (CVB3)-induced viral myocarditis is a common clinical cardiovascular
disease without effective available vaccine. In this study, we tried to potentiate the …

DNA vaccines delivered with electroporation (EP) have shown promising results in
preclinical models and are evaluated in clinical trials. In this study, we aim to characterize …