The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due
to the ability of degrader molecules to selectively modulate disease-relevant proteins. A key …

Targeted protein degradation (TPD) has emerged as an effective therapeutic strategy for a
wide range of diseases; however, the blood-brain barrier (BBB) limits access of degraders …

Highlights•Traditional antibodies block ligand binding or drive Fc effector
functions.•Bifunctional antibodies function through an induced proximity …

Many disease-causing proteins have multiple pathogenic mechanisms, and conventional
inhibitors struggle to reliably disrupt more than one. Targeted protein degradation (TPD) can …

Existing strategies use bifunctional chimaeras to mediate extracellular protein degradation.
However, these strategies rely on specific lysosome-trafficking receptors to facilitate …

A low-molecular-weight compound whose structure strikes a fine balance between
hydrophobicity and hydrophilicity may form coacervates via liquid–liquid phase separation …

Lysosome-targeting chimeras (LYTACs) are a promising therapeutic modality to drive the
degradation of extracellular proteins. However, early versions of LYTAC contain synthetic …

Lysosome-targeting chimeras (LYTACs) have recently been developed to facilitate the
lysosomal degradation of specific extracellular and transmembrane molecular targets …

WNT signaling is crucial for embryonic development, and adult tissue homeostasis and
regeneration, through its essential roles in cell fate, patterning, and stem cell regulation. The …

Degron tagging allows proteins of interest to be rapidly degraded, in a reversible and
tuneable manner, in response to a chemical stimulus. This provides numerous opportunities …