Central nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain
injury, causes severe neurological symptoms such as sensory and motor deficits. Currently …

Human in vitro models of brain neurophysiology are needed to investigate molecular and
cellular mechanisms associated with neurological disorders and neurotoxicity. We have …

Neurodevelopment is uniquely sensitive to toxic insults and there are concerns that
environmental chemicals are contributing to widespread subclinical developmental …

Scarce access to primary samples and lack of efficient protocols to generate
oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our …

Myelination is critical for transduction of neuronal signals, neuron survival and normal
function of the nervous system. Myelin disorders account for many debilitating neurological …

96-Well plate has been the traditional method used for screening drug compounds libraries
for potential bioactivity. Although this method has been proven successful in testing dose …

Myelin is of vital importance to the central nervous system and its disruption is related to a
large number of both neurodevelopmental and neurodegenerative diseases. The …

CNS myelination process involves proliferation and differentiation of oligodendrocyte
progenitor cells (OPCs). Defective myelination causes onset of neurological disorders …

Glial cells are mechanosensitive, and thus, engineered systems have taken a step forward
to design mechanotransduction platforms in order to impart diverse mechanical stresses to …

The correct targeting of myelin is essential for nervous system formation and function.
Oligodendrocytes in the CNS myelinate some axons, but not others, and do not myelinate …