There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

Gastrulation is the fundamental process in all multicellular animals through which the basic
body plan is first laid down,,–. It is pivotal in generating cellular diversity coordinated with …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

The human genome contains more than 4.5 million inserts derived from transposable
elements (TEs), the result of recurrent waves of invasion and internal propagation …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …