Fluorine (19F) MRS and MRI in biomedicine
Shortly after the introduction of 1H MRI, fluorinated molecules were tested as MR‐detectable
tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically …
tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically …
Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function
F Rohan Walker, M Nilsson, K Jones - Current drug targets, 2013 - ingentaconnect.com
Traditionally, microglia have been considered to act as macrophages of the central nervous
system. While this concept still remains true it is also becoming increasingly apparent that …
system. While this concept still remains true it is also becoming increasingly apparent that …
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by
multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the …
multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the …
A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia
Selective serotonin and serotonin norepinephrine reuptake inhibitors (SSRI; SNRI) are the
first choice pharmacological treatment options for major depression. It has long been …
first choice pharmacological treatment options for major depression. It has long been …
A comparison of the risk of QT prolongation among SSRIs
KA Funk, JR Bostwick - Annals of Pharmacotherapy, 2013 - journals.sagepub.com
Objective: To report QT prolongation potential in selective serotonin reuptake inhibitors
(SSRIs) in order to advise clinicians on safe use of SSRIs other than citalopram in light of …
(SSRIs) in order to advise clinicians on safe use of SSRIs other than citalopram in light of …
New frontiers and developing applications in 19F NMR
1.2. Background Fluorine NMR offers many attractive features, most notably detection
sensitivity approaching that of protons. 19 F has a nuclear spin I= 1/2, a gyromagnetic ratio …
sensitivity approaching that of protons. 19 F has a nuclear spin I= 1/2, a gyromagnetic ratio …
Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic …
AL Pehrson, C Sanchez - Drug design, development and therapy, 2015 - Taylor & Francis
Evidence suggesting that central nervous system γ-aminobutyric acid (GABA)
concentrations are reduced in patients with major depressive disorder (MDD) has been …
concentrations are reduced in patients with major depressive disorder (MDD) has been …
A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this …
FR Walker - Neuropharmacology, 2013 - Elsevier
The selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
pharmacological treatment for depression. Since their introduction many have considered …
pharmacological treatment for depression. Since their introduction many have considered …
Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes
Rationale The pharmacological actions of most antidepressants are ascribed to the
modulation of serotonergic and/or noradrenergic transmission in the brain. During …
modulation of serotonergic and/or noradrenergic transmission in the brain. During …
Pharmacological inhibition of Kir4. 1 evokes rapid-onset antidepressant responses
X Zhou, C Zhao, H Xu, Y Xu, L Zhan, P Wang… - Nature Chemical …, 2024 - nature.com
Major depressive disorder, a prevalent and severe psychiatric condition, necessitates
development of new and fast-acting antidepressants. Genetic suppression of astrocytic …
development of new and fast-acting antidepressants. Genetic suppression of astrocytic …