The role of collagen in cancer: from bench to bedside
S Xu, H Xu, W Wang, S Li, H Li, T Li, W Zhang… - Journal of translational …, 2019 - Springer
Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …
[HTML][HTML] A tough act to follow: Collagen hydrogel modifications to improve mechanical and growth factor loading capabilities
Collagen hydrogels are among the most well-studied platforms for drug delivery and in situ
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …
Mechanical and physical regulation of fibroblast–myofibroblast transition: from cellular mechanoresponse to tissue pathology
M D'Urso, NA Kurniawan - Frontiers in bioengineering and …, 2020 - frontiersin.org
Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …
Three-dimensional culture system of cancer cells combined with biomaterials for drug screening
T Nii, K Makino, Y Tabata - Cancers, 2020 - mdpi.com
Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …
Collagen microarchitecture mechanically controls myofibroblast differentiation
Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …
Unravelling cell migration: defining movement from the cell surface
F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
Biomaterial-assisted regenerative medicine
T Nii, Y Katayama - International journal of molecular sciences, 2021 - mdpi.com
This review aims to show case recent regenerative medicine based on biomaterial
technologies. Regenerative medicine has arousing substantial interest throughout the world …
technologies. Regenerative medicine has arousing substantial interest throughout the world …
3D in vitro M2 macrophage model to mimic modulation of tissue repair
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
Extracellular matrix mechanobiology in cancer cell migration
The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
Viscoelasticity in natural tissues and engineered scaffolds for tissue reconstruction
Viscoelasticity of living tissues plays a critical role in tissue homeostasis and regeneration,
and its implication in disease development and progression is being recognized recently. In …
and its implication in disease development and progression is being recognized recently. In …