Antibiofilm activity of host defence peptides: complexity provides opportunities
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …
[HTML][HTML] Reassessing the host defense peptide landscape
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
Peptides with dual antimicrobial and anticancer activities
In recent years, the number of people suffering from cancer and multi-resistant infections has
increased, such that both diseases are already seen as current and future major causes of …
increased, such that both diseases are already seen as current and future major causes of …
Red‐light‐mediated photoredox catalysis enables self‐reporting nitric oxide release for efficient antibacterial treatment
Nitric oxide (NO) serves as a key regulator of many physiological processes and as a potent
therapeutic agent. The local delivery of NO is important to achieve target therapeutic …
therapeutic agent. The local delivery of NO is important to achieve target therapeutic …
Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens
D Pletzer, SC Mansour, REW Hancock - PLoS pathogens, 2018 - journals.plos.org
With the antibiotic development pipeline running dry, many fear that we might soon run out
of treatment options. High-density infections are particularly difficult to treat due to their …
of treatment options. High-density infections are particularly difficult to treat due to their …
New perspectives in biofilm eradication
H Wolfmeier, D Pletzer, SC Mansour… - ACS infectious …, 2018 - ACS Publications
Microbial biofilms, which are elaborate and highly resistant microbial aggregates formed on
surfaces or medical devices, cause two-thirds of infections and constitute a serious threat to …
surfaces or medical devices, cause two-thirds of infections and constitute a serious threat to …
Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial
biofilms, disperse the microbial community and increase their susceptibility to antibiotics and …
biofilms, disperse the microbial community and increase their susceptibility to antibiotics and …
Design and assessment of anti-biofilm peptides: steps toward clinical application
M Dostert, CR Belanger, REW Hancock - Journal of innate immunity, 2019 - karger.com
Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-
threatening infections in humans. At least two-thirds of all clinical infections are biofilm …
threatening infections in humans. At least two-thirds of all clinical infections are biofilm …
New mouse model for chronic infections by gram-negative bacteria enabling the study of anti-infective efficacy and host-microbe interactions
Only a few, relatively cumbersome animal models enable long-term Gram-negative bacterial
infections that mimic human situations, where untreated infections can last for weeks. Here …
infections that mimic human situations, where untreated infections can last for weeks. Here …
Computer-aided discovery of peptides that specifically attack bacterial biofilms
EF Haney, Y Brito-Sánchez, MJ Trimble, SC Mansour… - Scientific reports, 2018 - nature.com
Biofilms represent a multicellular growth state of bacteria that are intrinsically resistant to
conventional antibiotics. It was recently shown that a synthetic immunomodulatory cationic …
conventional antibiotics. It was recently shown that a synthetic immunomodulatory cationic …