[HTML][HTML] The progression of geographic atrophy secondary to age-related macular degeneration
Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD)
that leads to progressive and irreversible loss of visual function. Geographic atrophy is …
that leads to progressive and irreversible loss of visual function. Geographic atrophy is …
Age-related macular degeneration: a review
M Fleckenstein, S Schmitz-Valckenberg… - JAMA, 2024 - jamanetwork.com
Importance Age-related macular degeneration (AMD) affects approximately 20 million
people in the US and 196 million people worldwide. AMD is a leading cause of severe …
people in the US and 196 million people worldwide. AMD is a leading cause of severe …
[HTML][HTML] C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2/3 trial
GJ Jaffe, K Westby, KG Csaky, J Monés, JA Pearlman… - Ophthalmology, 2021 - Elsevier
Purpose The complement pathway may play a key role in the pathogenesis of age-related
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …
[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …
is a major cause of blindness. Even while central visual acuity remains relatively well …
Efficacy and safety of lampalizumab for geographic atrophy due to age-related macular degeneration: Chroma and Spectri phase 3 randomized clinical trials
Importance Geographic atrophy (GA) secondary to age-related macular degeneration is a
leading cause of visual disability in older individuals. A phase 2 trial suggested that …
leading cause of visual disability in older individuals. A phase 2 trial suggested that …
Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial
Abstract Background/Objectives To assess the safety and efficacy of avacincaptad pegol
(ACP), a C5 inhibitor, for geographic atrophy (GA) secondary to age-related macular …
(ACP), a C5 inhibitor, for geographic atrophy (GA) secondary to age-related macular …
Age-related macular degeneration preferred practice pattern®
Background: Age-related macular degeneration is a leading cause of severe, irreversible
vision impairment in developed countries. The primary risk factors for the development of …
vision impairment in developed countries. The primary risk factors for the development of …
The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …
diseases. The recruitment and activation of both resident microglia and recruited …