Detection, clinical relevance and specific biological properties of disseminating tumour cells
Most cancer deaths are caused by haematogenous metastatic spread and subsequent
growth of tumour cells at distant organs. Disseminating tumour cells present in the …
growth of tumour cells at distant organs. Disseminating tumour cells present in the …
Circulating tumor cells (CTC) detection: clinical impact and future directions
P Paterlini-Brechot, NL Benali - Cancer letters, 2007 - Elsevier
Recent molecular and clinical studies have shown that invasion may occur very early in
tumor development, thus emphasizing the potential importance of specific and sensitive …
tumor development, thus emphasizing the potential importance of specific and sensitive …
Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics
Circulating tumor cells (CTCs) are rare cancer cells that are shed from primary or metastatic
tumors into the peripheral blood circulation. Phenotypic and genetic characterization of …
tumors into the peripheral blood circulation. Phenotypic and genetic characterization of …
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
WJ Allard, J Matera, MC Miller, M Repollet… - Clinical cancer …, 2004 - AACR
Purpose: The purpose of this study was to determine the accuracy, precision, and linearity of
the CellSearch system and evaluate the number of circulating tumor cells (CTCs) per 7.5 mL …
the CellSearch system and evaluate the number of circulating tumor cells (CTCs) per 7.5 mL …
Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device
The development of personalized cancer therapy depends on a robust system to monitor the
patient's individual response to anticancer treatment. Anticancer drug efficacy has been …
patient's individual response to anticancer treatment. Anticancer drug efficacy has been …
Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity
V Müller, N Stahmann, S Riethdorf, T Rau… - Clinical Cancer …, 2005 - AACR
Purpose: The incidence and biological characteristics of circulating tumor cells in the blood
of patients with breast cancer were examined and subgroups were evaluated in the context …
of patients with breast cancer were examined and subgroups were evaluated in the context …
Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
Purpose: The prognostic significance of serum interleukin (IL)-8 was evaluated in patients
with metastatic breast cancer. The predictive value of serum IL-8 for the presence of occult …
with metastatic breast cancer. The predictive value of serum IL-8 for the presence of occult …
Changes in keratin expression during metastatic progression of breast cancer: impact on the detection of circulating tumor cells
SA Joosse, J Hannemann, J Spötter, A Bauche… - Clinical Cancer …, 2012 - AACR
Purpose: Circulating tumor cells (CTC) might function as early markers for breast cancer
metastasis or monitoring therapy efficacy. Enrichment and identification of CTCs are based …
metastasis or monitoring therapy efficacy. Enrichment and identification of CTCs are based …
Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse—a European pooled analysis
W Janni, FD Vogl, G Wiedswang, M Synnestvedt… - Clinical Cancer …, 2011 - AACR
Background: The prognostic significance of disseminated tumor cells (DTC) in bone marrow
(BM) of breast cancer patients at the time of primary diagnosis has been confirmed by a …
(BM) of breast cancer patients at the time of primary diagnosis has been confirmed by a …
Comparison of two density gradient centrifugation systems for the enrichment of disseminated tumor cells in blood
R Rosenberg, R Gertler, J Friederichs… - … : The Journal of the …, 2002 - Wiley Online Library
Background The detection of disseminated tumor cells in peripheral blood is limited by the
presence of very few tumor cells within a large number of blood cells. Therefore, tumor cell …
presence of very few tumor cells within a large number of blood cells. Therefore, tumor cell …