Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

The complex neuronal networks of the spinal cord coordinate a wide variety of motor
functions, including walking, running, and voluntary and involuntary movements. This is …

Although Renshaw cells (RCs) were discovered over half a century ago, their precise role in
recurrent inhibition and ability to modulate motoneuron excitability have yet to be …

Renshaw cells represent a fundamental component of one of the first discovered neuronal
circuits, but their function in motor control has not been established. They are the only …

Renshaw cells provide a convenient model to study spinal circuit development during the
emergence of motor behaviors with the goal of capturing principles of interneuron …

The corelease of several neurotransmitters from a single synaptic vesicle has been
observed at many central synapses. Nevertheless, the signaling synergy offered by …

In neonatal mice motoneurons excite Renshaw cells by releasing both acetylcholine (ACh)
and glutamate. These two neurotransmitters activate two types of nicotinic receptors …

Central nervous system GABAergic and glycinergic synaptic activity switches from
postsynaptic excitation to inhibition during the stage when motor neuron numbers are being …

Hyperekplexia is a rare human neuromotor disorder caused by mutations that impair the
efficacy of glycinergic inhibitory neurotransmission. Loss-of-function mutations in the GLRA1 …

Motoneurons have long been considered as the final common pathway of the nervous
system, transmitting the neural impulses that are transduced into action. While many studies …