Psychiatric disorders are one of the biggest burdens to society, with significant personal and
economical costs. Schizophrenia (SCZ), among them, is still poorly understood, and its …

Background: Although genetic studies suggest an overlap in risk alleles across the major
psychiatric disorders, disease signatures reflecting overlapping symptoms have not been …

Background: Extensive research efforts have generated genomic, transcriptomic, proteomic,
and functional data hoping to elucidate psychiatric pathophysiology. Selected reaction …

Bipolar disorder (BD) is a complex and costly psychiatric disorder, which affects one
hundred million people worldwide. Due to its heterogeneity, correct BD diagnosis is still a …

Abstract Deletions on chromosome 22q11. 2 are a strong genetic risk factor for development
of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography …

Peripheral blood mononuclear cells (PBMCs) have been used as a surrogate model of
immune function in studies of multiple medical areas, such as metabolic diseases and …

Mental health is increasingly being recognized as both a leading cause of disability
worldwide and an important area of opportunity for biological breakthroughs. A major …

Background: Depression affects over 120 million individuals of all ages and is the leading
cause of disability worldwide. The lack of objective diagnostic criteria, together with the …

Протеомика–направление, которое изучает состав и изменения спектра белков в
конкретных физиологических условиях. Нейропротеомика, как особая субдисциплина …

Stable isotope labelling by amino acids in cell culture (SILAC) is a technique that allows
proteomic profiling of cells. In this chapter we describe a protocol for the identification and …