Depression is a highly prevalent, disabling, and often chronic illness that places substantial
burdens on patients, families, healthcare systems, and the economy. A substantial minority …

The relationship between depression, its etiology and therapy, and the cAMP signaling
system have been studies for decades. This review will focus on cAMP, G proteins and …

In contrast to healthy controls, the heterotrimeric G protein, Gsalpha (Gsα) is ensconced
predominantly in lipid rafts in subjects with major depressive disorder (MDD) resulting in …

Introduction Major depressive disorder is caused by gene–environment interactions, and the
host microbiome has been recognized as an important environmental factor. However, the …

Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …

Chronic stress is one of the key precipitating factors in major depressive disorder (MDD).
Stress associated studies have underscored the mechanistic role of epigenetic master …

Introduction Biological factors are known to be important in understanding the pathogenesis
of Major Depressive Disorder (MDD). Oxidative stress and neuroinflammation pathways are …

Major depressive disorder (MDD) is a leading global cause of disability, being more
prevalent in females, possibly due to molecular and neuronal pathway differences between …

Objective Our laboratory has recently shown that there is a decrease in neuronal complexity
in head pain processing regions in mouse models of chronic migraine‐associated pain and …

Introduction Major depressive disorder (MDD) is a prevalent and debilitating mental disorder
that shares symptoms, genetics, and molecular changes in the brain with other psychiatric …