Historically, research into the lymphatic system has been overlooked due to both a lack of
knowledge and limited recognition of its importance. In the last decade however, lymphatic …

Subcutaneous (subQ) injection is a common route for delivering biotherapeutics, wherein
pharmacokinetics is largely influenced by drug transport in a complex subQ tissue …

This paper studies the transport of monoclonal antibodies through skin tissue and initial
lymphatics, which impacts the pharmacokinetics of monoclonal antibodies. Our model …

Simple Summary The lymphatic system plays a crucial role in maintaining fluid and solute
balance in biological tissue, which makes the subcutaneous injection a common approach …

Lymphatic uptake is essential for transporting nutrients, wastes, immune cells, and
therapeutic proteins. Despite its importance, the literature lacks a quantitative analysis of the …

The lymphatic system is active in several processes that regulate human diseases, among
which cancer progression stands out. Thus, various drug delivery systems have been …

The subcutaneous injection is the most common method of administration of monoclonal
antibodies (mAbs) due to the patient's comfort and cost-effectiveness. However, the …

Several studies have recommended the use of hydrogels for localized targeted delivery of
chemotherapeutic drugs following tumor removal surgery. This approach aims to both fill the …

The lymphatic system (LS) is a circulatory system composed of lymph vessels, which are
similar to blood vessels. It gets rid of fluid (lymph) that has seeped into the tissues from the …