Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Cyclooxygenase-derived prostanoids exert complex and diverse functions within the kidney.
The biological effect of each prostanoid is controlled at multiple levels, including (a) …

Permeability edema is a life-threatening complication accompanying acute lung injury (ALI),
severe pneumonia and the acute respiratory distress syndrome (ARDS), which can be …

Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in
excessive extracellular matrix accumulation and anatomic remodeling. Current therapies for …

Small lipids such as eicosanoids exert diverse and complex functions. In addition to their
role in regulating normal kidney function, these lipids also play important roles in the …

We rescued the embryonic lethality of global PPARγ knockout by breeding Mox2-Cre
(MORE) mice with floxed PPARγ mice to inactivate PPARγ in the embryo but not in …

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible deterioration
of the airway wall. Cigarette smoking is the major trigger, and in vitro studies showed that …

Asthma represents one of the leading chronic diseases worldwide and causes a high global
burden of death and disability. In asthmatic patients, the exacerbation and chronification of …

Lung epithelium is the primary site of lung damage in various lung diseases. Epithelial cell
apoptosis has been considered to be initial event in various lung diseases. Apoptosis …

Objective To evaluate the antifibrotic effects of the pan-peroxisome proliferator-activated
receptor (PPAR) agonist IVA337 in preclinical mouse models of pulmonary fibrosis and …