Branch site recognition by the spliceosome

J Tholen - RNA, 2024 - rnajournal.cshlp.org
The spliceosome is a eukaryotic multimegadalton RNA–protein complex that removes
introns from transcripts. The spliceosome ensures the selection of each exon-intron …

Structural basis of 5′ splice site recognition by the minor spliceosome

J Zhao, D Peter, I Brandina, X Liu, WP Galej - Molecular Cell, 2025 - cell.com
The minor spliceosome catalyzes excision of U12-dependent introns from precursors of
eukaryotic messenger RNAs (pre-mRNAs). This process is critical for many cellular …

Connecting genotype and phenotype in minor spliceosome diseases

AJ Norppa, MV Shcherbii, MJ Frilander - RNA, 2025 - rnajournal.cshlp.org
Minor spliceosome is responsible for recognizing and excising a specific subset of divergent
introns during the pre-mRNA splicing process. Mutations in the unique snRNA and protein …

[HTML][HTML] Role of U11/U12 minor spliceosome gene ZCRB1 in Ciliogenesis and WNT Signaling

G Powell-Rodgers, MUR Pirzada, J Richee… - …, 2024 - pmc.ncbi.nlm.nih.gov
Despite the fact that 0.5% of human introns are processed by the U11/U12 minor
spliceosome, the latter influences gene expression across multiple cellular processes. The …

Novel strategies for identification and characterisation of autoantibodies in Systemic Sclerosis

J Perurena Prieto - tdx.cat
The presence of autoantibodies is a serological hallmark of SSc, as it has been reported that
95% of patients present anti-nuclear autoantibodies (ANAs) by indirect immunofluorescence …