Heart failure with preserved ejection fraction in perspective

MA Pfeffer, AM Shah, BA Borlaug - Circulation research, 2019 - Am Heart Assoc
Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding

SJ Simmonds, I Cuijpers, S Heymans, EAV Jones - Cells, 2020 - mdpi.com
Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association …

B Pieske, C Tschöpe, RA De Boer… - European heart …, 2019 - academic.oup.com
Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF)
remains a challenge. We recommend a new stepwise diagnostic process, the 'HFA–PEFF …

[PDF][PDF] Pathophysiology of heart failure

E Tanai, S Frantz - Compr Physiol, 2015 - researchgate.net
Heart failure is considered an epidemic disease in the modern world affecting approximately
1% to 2% of adult population. It presents a multifactorial, systemic disease, in which—after …

Empagliflozin ameliorates diastolic dysfunction and left ventricular fibrosis/stiffness in nondiabetic heart failure: a multimodality study

CG Santos-Gallego, JA Requena-Ibanez… - Cardiovascular …, 2021 - jacc.org
Objectives The purpose of this study was to investigate the effect of empagliflozin on
diastolic function in a nondiabetic heart failure with reduced ejection fraction (HFrEF) …

Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?

M Sweeney, B Corden, SA Cook - EMBO molecular medicine, 2020 - embopress.org
Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

The pathophysiology of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2014 - nature.com
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …

Impaired systolic function by strain imaging in heart failure with preserved ejection fraction

E Kraigher-Krainer, AM Shah, DK Gupta… - Journal of the American …, 2014 - jacc.org
Objectives: This study sought to determine the frequency and magnitude of impaired systolic
deformation in heart failure with preserved ejection fraction (HFpEF). Background: Although …

Effect of personalized accelerated pacing on quality of life, physical activity, and atrial fibrillation in patients with preclinical and overt heart failure with preserved …

M Infeld, K Wahlberg, J Cicero, TB Plante… - JAMA …, 2023 - jamanetwork.com
Importance Patients with heart failure with preserved ejection fraction (HFpEF) with a
pacemaker may benefit from a higher, more physiologic backup heart rate than the nominal …

Invasive left ventricle pressure–volume analysis: overview and practical clinical implications

MB Bastos, D Burkhoff, J Maly, J Daemen… - European heart …, 2020 - academic.oup.com
Ventricular pressure–volume (PV) analysis is the reference method for the study of cardiac
mechanics. Advances in calibration algorithms and measuring techniques brought new …