Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high
prevalence and lethality. However, the underlying mechanism for HCC has not been entirely …

LncRNAs are emerging as integral functional and regulatory components of normal
biological activities and are now considered as critically involved in the development of …

Tumor–stromal interaction is a dynamic process that promotes tumor growth and metastasis
via cell–cell interaction and extracellular vesicles. Recent studies demonstrate that stromal …

Long non-coding RNAs (lncRNAs) are over 200 nucleotides in length and are transcribed
from the mammalian genome in a tissue-specific and developmentally regulated pattern …

Hepatocellular carcinoma (HCC) is associated with poor survival for patients and few
effective treatment options, raising the need for novel therapeutic strategies. MicroRNAs …

Purpose: MicroRNAs in the delta-like 1 homolog–deiodinase, iodothyronine 3 (DLK1-DIO3)
cluster have been shown to be critical for embryonic development and epithelial to …

We previously utilized a Sleeping Beauty (SB) transposon mutagenesis screen to discover
novel drivers of HCC. This approach identified recurrent mutations within the Dlk1-Dio3 …

Lgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various
organs. However, whether Lgr4 and Lgr5 are important for embryonic development remains …

Aberrant DNA methylation is a common feature of neoplastic lesions, and early detection of
such changes may provide powerful mechanistic insights and biomarkers for …

Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …