The mammalian brain is composed of diverse, specialized cell populations. To
systematically ascertain and learn from these cellular specializations, we used Drop-seq to …

Creatine provides cells with high-energy phosphates for the rapid reconstitution of
hydrolyzed adenosine triphosphate. The eponymous creatine transporter (CRT1/SLC6A8) …

Impaired cardiac energy metabolism has been proposed as a mechanism common to
different heart failure aetiologies. The energy-depletion hypothesis was pursued by several …

Botulinum neurotoxin Type A (BoNT/A) is an effective treatment for several movement
disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal …

Mutations in the solute carrier family 6-member 8 (Slc6a8) gene, encoding the protein
responsible for cellular creatine (Cr) uptake, cause Creatine Transporter Deficiency (CTD) …

Diseases arising from misfolding of SLC6 transporters have been reported over recent
years, eg. folding-deficient mutants of the dopamine transporter and of the glycine …

With an ever aging population, identifying interventions that can alleviate age-related
functional declines has become increasingly important. Dietary supplements have taken …

Abstract Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting
with intellectual disability, behavioral disturbances and epilepsy. There is currently no cure …

Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP,
important in tissues with high energy demand such as muscle or brain. Creatine is taken …

Creatine serves as fast energy buffer in organs of high-energy demand such as brain and
skeletal muscle. l-Arginine: glycine amidinotransferase (AGAT) and guanidinoacetate N …