Background Immunohistochemistry (IHC) is a well-established, widely accepted method in
both clinical and experimental parts of medical science. It allows receiving valuable …

Abstract Evaluation of tissues is a common and important aspect of translational research
studies. Labeling techniques such as immunohistochemistry can stain cells/tissues to …

Acute kidney injury (AKI) is not only a worldwide problem with a cruel hospital mortality rate
but also an independent risk factor for chronic kidney disease and a promoting factor for its …

Lactate was implicated in the activation of hepatic stellate cells (HSCs). However, the
mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag …

Semi-quantitative IHC is a powerful method for investigating protein expression and
localization within tissues. The semi-quantitative immunohistochemistry (IHC) involves using …

Abstract N 6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory
mechanism affecting cell differentiation and proliferation in development and cancer. To …

Deep tissue imaging in the second near-infrared (NIR-II) window holds great promise for
physiological studies and biomedical applications,,,,–. However, inhomogeneous signal …

Ferroptosis, a type of cell death triggered by excessive accumulation of iron-dependent lipid
peroxidation, possesses an excellent potential in cancer treatment. However, many …

Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA
breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or …

Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …