Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes
TA Rapoport - Nature, 2007 - nature.com
A decisive step in the biosynthesis of many proteins is their partial or complete translocation
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology
CJ Guerriero, JL Brodsky - Physiological reviews, 2012 - journals.physiology.org
Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries …
by-product. These by-products can be recognized by cellular quality control machineries …
[图书][B] Biochemistry
D Voet, JG Voet - 2010 - books.google.com
The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that
has been thoroughly revised. Don and Judy Voet explain biochemical concepts while …
has been thoroughly revised. Don and Judy Voet explain biochemical concepts while …
Structural insight into the biogenesis of β-barrel membrane proteins
Abstract β-barrel membrane proteins are essential for nutrient import, signalling, motility and
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …
Mechanisms of regulated unconventional protein secretion
W Nickel, C Rabouille - Nature reviews Molecular cell biology, 2009 - nature.com
Most eukaryotic proteins are secreted through the conventional endoplasmic reticulum (ER)–
Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide-containing …
Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide-containing …
[HTML][HTML] Sec-and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—distinct translocases and mechanisms
In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane.
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
The function, structure, and origins of the ER membrane protein complex
RS Hegde - Annual Review of Biochemistry, 2022 - annualreviews.org
The endoplasmic reticulum (ER) is the site of membrane protein insertion, folding, and
assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical …
assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical …
[HTML][HTML] Consequences of membrane protein overexpression in Escherichia coli
S Wagner, L Baars, AJ Ytterberg, A Klussmeier… - Molecular & Cellular …, 2007 - Elsevier
Overexpression of membrane proteins is often essential for structural and functional studies,
but yields are frequently too low. An understanding of the physiological response to …
but yields are frequently too low. An understanding of the physiological response to …
Signal peptides generated by attention-based neural networks
Short (15–30 residue) chains of amino acids at the amino termini of expressed proteins
known as signal peptides (SPs) specify secretion in living cells. We trained an attention …
known as signal peptides (SPs) specify secretion in living cells. We trained an attention …