The departure into unknown chemical space is essential for the discovery of new properties
and function. We herein report the first synthetic access to N‐trifluoromethylated formamides …

In recent decades, obesity has become a pandemic disease and appears to be an ultimate
medical and social problem. Existing antiobesity drugs show low efficiency and a wide …

The alkyne zipper reaction is an internal-to-terminal alkyne isomerization reaction with many
interesting applications in synthetic chemistry, as it constitutes an efficient means of …

The ligation of sterically demanding peptidyl sites such as those involving Val–Val and Val–
Pro linkages has proven to be extremely challenging with conventional NCL methods that …

A series of new 1, ω-bis-(5-alkyl-3-tosyl-1, 3, 4, 2-triazaphospholino) alkanes 2 and 3 were
obtained in excellent yields by the condensation of 1, ω-bis-(1-tosylamidrazone) alkanes 1 …

Tetrahydrolipstatin (THL), its enantiomer, and an additional six diastereomers were
evaluated as inhibitors of the hydrolysis of p-nitrophenyl butyrate by porcine pancreatic …

The de novo asymmetric synthesis of all possible stereoisomers of two polyketide natural
products, avocadyne, avocadene, and the saturated variant avocadane, is described. The …

Fusidic acid is a translation inhibitor with activity against major Gram-positive bacterial
pathogens such as S. aureus. However, its activity against Gram-negatives is poor based on …

An asymmetric approach toward the synthesis of the marine natural product aspergillide‐C
has been developed. The convergent asymmetric synthesis uses two asymmetric Noyori …

Tetrahydrolipstatin (THL, 1a) has been shown to inhibit both mammalian and bacterial α/β
hydrolases. In the case of bacterial systems, THL is a known inhibitor of several …