Platelet-rich plasma for managing pain and inflammation in osteoarthritis

I Andia, N Maffulli - Nature Reviews Rheumatology, 2013 - nature.com
Osteoarthritis (OA) is a common disease involving joint damage, an inadequate healing
response and progressive deterioration of the joint architecture. Autologous blood-derived …

Biology of platelet-rich plasma and its clinical application in cartilage repair

X Xie, C Zhang, RS Tuan - Arthritis research & therapy, 2014 - Springer
Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and
inflammatory mediators, and has been considered to be potentially effective for cartilage …

Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis

JC Riboh, BM Saltzman, AB Yanke… - … American journal of …, 2016 - journals.sagepub.com
Background: Leukocyte-poor platelet-rich plasma (LP-PRP) is hypothesized to be more
suitable for intra-articular injection than leukocyte-rich PRP (LR-PRP) in the treatment of …

The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis

EA Sundman, BJ Cole, V Karas… - … American journal of …, 2014 - journals.sagepub.com
Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis
(OA) results in improved patient-reported pain and function scores. Purpose: To measure the …

Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration

G Filardo, E Kon, A Roffi, B Di Matteo, ML Merli… - Knee Surgery, Sports …, 2015 - Springer
Purpose The aim of this review was to analyze the available evidence on the clinical
application of this biological approach for the injective treatment of cartilage lesions and joint …

Platelet-rich plasma: underlying biology and clinical correlates

I Andia, M Abate - Regenerative medicine, 2013 - Taylor & Francis
Platelet-rich plasma (PRP) has recently become the focus of intensive interest and
discussion, in part because of the expanding understanding of platelet function. Anucleate …

The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis

A Khoshbin, T Leroux, D Wasserstein, P Marks… - … : The Journal of …, 2013 - Elsevier
Purpose The purpose of this systematic review was to synthesize the available Level I and
Level II literature on platelet-rich plasma (PRP) as a therapeutic intervention in the …

Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery

MM Murray, BC Fleming - The American journal of sports …, 2013 - journals.sagepub.com
Background: Although anterior cruciate ligament (ACL) reconstruction is the treatment gold
standard for ACL injury, it does not reduce the risk of posttraumatic osteoarthritis. Therefore …

Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

WH Chen, WC Lo, WC Hsu, HJ Wei, HY Liu, CH Lee… - Biomaterials, 2014 - Elsevier
Osteoarthritis (OA) is a common disease associated with tissue inflammation, physical
disability and imbalanced homeostasis in cartilage. For advanced treatments, biological …

Platelet-rich plasma in the pathologic processes of cartilage: review of basic science evidence

NA Smyth, CD Murawski, LA Fortier, BJ Cole… - … : The Journal of …, 2013 - Elsevier
Purpose The purpose of this study was to systematically review the basic science evidence
for the use of platelet-rich plasma (PRP) in the treatment of pathologic processes of …