Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

The PE and PPE proteins of Mycobacterium tuberculosis have been studied with great
interest since their discovery. Named after the conserved proline (P) and glutamic acid (E) …

The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …

Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …

Tuberculosis (TB) affects humans and other animals and is caused by bacteria from the
Mycobacterium tuberculosis complex (MTBC). Previous studies have shown that there are at …

Pyroptosis, an inflammatory form of programmed cell death, has been implicated in
eliminating pathogenic infections. However, macrophage pyroptosis–related proteins from …

Ubiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host
defense against intracellular pathogens including Mycobacterium tuberculosis (Mtb) …

Background Tracking recent transmission is a vital part of controlling widespread pathogens
such as Mycobacterium tuberculosis. Multiple methods with specific performance …

A small number of high-burden countries account for the majority of tuberculosis cases
worldwide. Detailed data are lacking from these regions. To explore the evolutionary history …

Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains the
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …