Progesterone actions and resistance in gynecological disorders

JA MacLean, K Hayashi - Cells, 2022 - mdpi.com
Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …

Progesterone resistance in endometriosis: an acquired property?

B McKinnon, M Mueller, G Montgomery - Trends in Endocrinology & …, 2018 - cell.com
Endometriosis is the growth of endometrial tissue outside the uterus and is characterized by
progesterone resistance and changes in global and progesterone target gene expression …

Loss of HDAC3 results in nonreceptive endometrium and female infertility

TH Kim, JY Yoo, KC Choi, JH Shin, RE Leach… - Science translational …, 2019 - science.org
Endometriosis is a disease in which tissue that normally grows inside the uterus grows
outside the uterus and causes chronic pelvic pain and infertility. However, the exact …

Aberrant endometrial DNA methylome and associated gene expression in women with endometriosis

S Houshdaran, CR Nezhat, KC Vo… - Biology of …, 2016 - academic.oup.com
Endometriosis is an estrogen-dependent, progesterone-resistant disorder largely derived
from retrograde transplantation of menstrual tissue/cells into the pelvis, eliciting an …

[HTML][HTML] DNA methylation in endometriosis

O Koukoura, S Sifakis… - Molecular medicine …, 2016 - spandidos-publications.com
Endometriosis is defined by the presence and growth of functional endometrial tissue,
outside the uterine cavity, primarily in the ovaries, pelvic peritoneum and rectovaginal …

Histological and immunohistochemical characterization of the similarity and difference between ovarian endometriomas and deep infiltrating endometriosis

X Liu, Q Zhang, SW Guo - Reproductive Sciences, 2018 - journals.sagepub.com
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) have long been
recognized to have different histology and, as such, postulated to be 2 separate disease …

Peritoneal fluid progesterone and progesterone resistance in superficial endometriosis lesions

PR Koninckx, A Ussia, L Adamyan, V Gomel… - Human …, 2022 - academic.oup.com
Peritoneal fluid in ovulatory women is an ovarian exudate with higher estrogen and
progesterone concentrations than in plasma. In the follicular phase, progesterone …

Role of oxidative stress in epigenetic modification in endometriosis

F Ito, Y Yamada, A Shigemitsu… - Reproductive …, 2017 - journals.sagepub.com
Aberrant DNA methylation and histone modification are associated with an increased risk of
reproductive disorders such as endometriosis. However, a cause–effect relationship …

Progesterone alleviates endometriosis via inhibition of uterine cell proliferation, inflammation and angiogenesis in an immunocompetent mouse model

Y Li, MK Adur, A Kannan, J Davila, Y Zhao, RA Nowak… - PloS one, 2016 - journals.plos.org
Endometriosis, defined as growth of the endometrial cells outside the uterus, is an
inflammatory disorder that is associated with chronic pelvic pain and infertility in women of …

Correlation between dioxin and endometriosis: an epigenetic route to unravel the pathogenesis of the disease

V Sofo, M Götte, AS Laganà, FM Salmeri… - Archives of gynecology …, 2015 - Springer
Introduction Environmental toxicants can act as endocrine disrupters on the female
reproductive system. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is resistant to …