Three‐dimensional stem cell models of mammalian gastrulation
DA Turner, A Martinez Arias - BioEssays, 2024 - Wiley Online Library
Gastrulation is a key milestone in the development of an organism. It is a period of cell
proliferation and coordinated cellular rearrangement, that creates an outline of the body …
proliferation and coordinated cellular rearrangement, that creates an outline of the body …
Retinoid-enhanced human gastruloids
A Schauer, JV Veenvliet - Nature Cell Biology, 2024 - nature.com
Hidden by the womb, early human development remains cloaked in mystery. To unveil
developmental processes in health and disease, pluripotent stem cells can be coaxed into …
developmental processes in health and disease, pluripotent stem cells can be coaxed into …
Mapping mouse axial progenitor dynamics in vitro
Y Miao, O Pourquié - Developmental Cell, 2024 - Elsevier
In this issue of Developmental Cell, Bolondi et al. systematically assesses neuro-
mesodermal progenitor (NMP) dynamics by combining a mouse stem-cell-based embryo …
mesodermal progenitor (NMP) dynamics by combining a mouse stem-cell-based embryo …
Inferring cell differentiation maps from lineage tracing data
During development, mulitpotent cells differentiate through a hierarchy of increasingly
restricted progenitor cell types until they realize specialized cell types. A cell differentiation …
restricted progenitor cell types until they realize specialized cell types. A cell differentiation …
Reporter CRISPR screens decipher cis-and trans-regulatory principles at the Xist locus
Developmental genes are controlled by an ensemble of cis-acting regulatory elements
(REs), which in turn respond to multiple trans-acting transcription factors (TFs) …
(REs), which in turn respond to multiple trans-acting transcription factors (TFs) …