Lysosomal stress response (LSR): physiological importance and pathological relevance
Extensive work has characterized endoplasmic reticulum (ER) and mitochondrial stress
responses. In contrast, very little has been published about stress responses in lysosomes; …
responses. In contrast, very little has been published about stress responses in lysosomes; …
Drug sequestration in lysosomes as one of the mechanisms of chemoresistance of cancer cells and the possibilities of its inhibition
J Hraběta, M Belhajová, H Šubrtová… - International journal of …, 2020 - mdpi.com
Resistance to chemotherapeutics and targeted drugs is one of the main problems in
successful cancer therapy. Various mechanisms have been identified to contribute to drug …
successful cancer therapy. Various mechanisms have been identified to contribute to drug …
Targeting acidogenic metabolism by engineering self-catalytic siRNA nanocarriers/nanocatalysts for amplified tumor apoptosis/ferroptosis
Nanocatalytic medicine holds great potential in inhibiting tumor progression based on the
synergistic catalytic production of toxic reactive oxygen species (ROS) between fenton …
synergistic catalytic production of toxic reactive oxygen species (ROS) between fenton …
Role of endolysosomes in severe acute respiratory syndrome coronavirus-2 infection and coronavirus disease 2019 pathogenesis: implications for potential …
N Khan, X Chen, JD Geiger - Frontiers in pharmacology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-
stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease known as …
stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease known as …
Facile synthesis of lactoferrin conjugated ultra small large pore silica nanoparticles for the treatment of glioblastoma
The blood brain barrier (BBB) and blood tumour barrier (BTB) remain a major roadblock for
delivering therapies to treat brain cancer. Amongst brain cancers, glioblastoma (GBM) is …
delivering therapies to treat brain cancer. Amongst brain cancers, glioblastoma (GBM) is …
Overcoming chemoresistance: Altering pH of cellular compartments by chloroquine and hydroxychloroquine
PW Halcrow, JD Geiger, X Chen - Frontiers in Cell and …, 2021 - frontiersin.org
Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a
major issue for people living with cancer and their providers. A diverse set of cellular and …
major issue for people living with cancer and their providers. A diverse set of cellular and …
Warburg effect and its role in tumourigenesis
Glucose is a crucial molecule in energy production and produces different end products in
non-tumourigenic-and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose …
non-tumourigenic-and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose …
Role of endolysosome function in iron metabolism and brain carcinogenesis
Iron, the most abundant metal in human brain, is an essential microelement that regulates
numerous cellular mechanisms. Some key physiological roles of iron include oxidative …
numerous cellular mechanisms. Some key physiological roles of iron include oxidative …
[HTML][HTML] Possible protective role of 17β-estradiol against COVID-19
N Khan - Journal of allergy and infectious diseases, 2020 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the virus that causes
coronavirus disease 2019 (COVID-19); a worldwide pandemic as declared by the World …
coronavirus disease 2019 (COVID-19); a worldwide pandemic as declared by the World …
Esomeprazole overcomes paclitaxel‐resistance and enhances anticancer effects of paclitaxel by inducing autophagy in A549/Taxol cells
Z Bai, N Ding, J Ge, Y Wang, L Wang… - Cell Biology …, 2021 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC) is one of the most common malignancies, and the
occurrence of drug‐resistance severely limits the efficacy of anticancer drugs in the …
occurrence of drug‐resistance severely limits the efficacy of anticancer drugs in the …