Inflammation is strongly linked to cancer and is essential for the growth and development of
tumors. Targeting inflammation and the mediators involved in the inflammatory process …

In the present work, novel 16 indole-based thalidomide analogs were designed and
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …

A niosomal formula of acemetacin was developed to improve its tumor targeting and radio-
kinetic evaluation was performed using 131 I. Niosomes were prepared by ether injection …

A novel series of quinoline-based benzamide derivatives was designed and synthesized as
histone deacetylase (HDAC) inhibitors and anticancer agents. The cytotoxic activity of the …

Non‐steroidal anti‐inflammatory drugs (NSAIDs) are extensively prescribed pharmaceutical
agents worldwide. Due to their analgesic, antipyretic, and anti‐inflammatory properties, they …

Multidrug-resistant microorganisms have become a global health problem, prompting
research into new antimicrobials. Drug repurposing is a new technique in drug discovery …

Targeted therapies have come into prominence in the ongoing battle against non-small cell
lung cancer (NSCLC) because of the shortcomings of traditional chemotherapy. In this …

Despite the tremendous progress that has occurred in recent years in cell biology and
oncology, in chemical, physical and computer sciences, the disease cancer has continued …

There are few studies for the preparation of dimers with biological activity. In this research,
two indomethacin dimers were prepared from indomethacin and characterized by NMR …

The goal of the doctoral research was to prove the improved pharmacological and safety
profile of some new indomethacin nitric oxide donors (indometacin-NO donors) which were …