Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …

Light-emitting diodes (LEDs) are taking an increasing place in the market of domestic
lighting because they produce light with low energy consumption. In the EU, by 2016, no …

The photoreceptor/RPE complex must maintain a delicate balance between maximizing the
absorption of photons for vision and retinal image quality while simultaneously minimizing …

Aims With ageing extracellular material is deposited in Bruch's membrane, as drusen.
Lipofuscin is deposited in retinal pigment epithelial cells. Both of these changes are …

Accumulation of vitamin A-derived lipofuscin fluorophores in the retinal pigment epithelium
(RPE) is a pathologic feature of recessive Stargardt macular dystrophy, a blinding disease …

Fluorescent bisretinoids, such as A2E and all-trans-retinal dimer, form as a by-product of
vitamin A cycling in retina and accumulate in retinal pigment epithelial (RPE) cells as …

Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are
characteristic age-related changes of post-mitotic retinal pigment epithelial (RPE) cells in the …

Every 5 years or so new technologies, or new combinations of old ones, seemingly burst
onto the science scene and are then sought after until they reach the point of becoming …

Lipofuscin accumulates with age as intracellular fluorescent granules originating from
incomplete lysosomal digestion of phagocytosed and autophagocytosed material. The …

Age-related macular degeneration, Stargardt disease, and their Abca4-/-mouse model are
characterized by accelerated accumulation of the pigment lipofuscin, derived from …