Ribosomes that stall during translation need to be rescued to ensure that the protein
synthesis capacity of the cell is maintained. Stalling arises when ribosomes become trapped …

In addition to the small and large ribosomal subunits, aminoacyl-tRNAs, and an mRNA,
cellular protein synthesis is dependent on translation factors. The eukaryotic translation …

Translation factor eIF5A, containing the unique amino acid hypusine, was originally shown
to stimulate Met-puromycin synthesis, a model assay for peptide bond formation. More …

Elongation factor P (EF-P) is a translation factor of unknown function that has been
implicated in a great variety of cellular processes. Here, we show that EF-P prevents …

Translation elongation factor P (EF-P) is critical for virulence in bacteria. EF-P is present in
all bacteria and orthologous to archaeal and eukaryotic initiation factor 5A, yet the biological …

Background While human gut microbiomes vary significantly in taxonomic composition,
biological pathway abundance is surprisingly invariable across hosts. We hypothesized that …

Due to their unique characteristics, which are not shared by canonical α-peptides, peptides
that contain stretches of consecutive β-amino acids are attractive scaffolds for novel peptide …

Pyrrolysyl-tRNA synthetase (PylRS) and its cognate tRNAPyl have emerged as ideal
translation components for genetic code innovation. Variants of the enzyme facilitate the …

Mollicutes is a class of parasitic bacteria that have evolved from a common Firmicutes
ancestor mostly by massive genome reduction. With genomes under 1 Mbp in size, most …

The peptide bond formation with the amino acid proline (Pro) on the ribosome is slow,
resulting in translational stalling when several Pro have to be incorporated into the peptide …